Quantification of short-term slow wave sleep homeostasis and its disruption by minocycline in the laboratory mouse

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Publication year: 2010Source: Neuroscience Letters, In Press, Accepted Manuscript, Available online 24 November 2010Jonathan P., Wisor , William C., ClegernElectroencephalographic slow wave activity (SWA) during slow wave sleep (SWS) undergoes dynamic fluctuations in reaction to sleep/wake history. SWA increases as a consequence of prior waking and decreases as consequence of prior SWS. These fluctuations are evidence for a homeostatic regulatory process, the neurobiological underpinnings of which remain to be defined. The anti-neuroinflammatory agent minocycline abolishes the increase in SWA that normally occurs after 1- or 3-hr sleep deprivation. We sought to determine whether this effect is also observed during spontaneous sleep. We describe a novel procedure for measuring the predictive relationship between spontaneous changes in sleep/wake states in the...